We are the makers of our own lives. There is no such thing as fate. Our lives are the result of our previous actions, our karma, and it naturally flows that, having been ourselves the makers of our karma, we must also be able to unmake it.
Dependent Origination is the teaching (that life) is not the mere play of blind chance, but has an existence that is dependent upon conditions. That, precisely with the removal of these conditions, those things that have arisen in dependence upon them-thus also all suffering-must perforce disappear and cease to be.