One should not pursue goals that are easily achieved. One must develop an instinct for what one can just barely achieve through one’s greatest efforts.
Destiny urges me to a goal of which I am ignorant. Until that goal is attained I am invulnerable, unassailable. When Destiny has accomplished her purpose in me, a fly may suffice to destroy me.
Do not wish for quick results, nor look for small advantages. If you seek quick results, you will not reach the ultimate goal. If you are led astray by small advantages, you will never accomplish great things.
Many people and companies only have one goal: money, money, and more money. Greed is ok when you let others profit from it, but greed for oneself is bad, it makes you ill.
To remain indifferent to the challenges we face is indefensible. If the goal is noble, whether or not it is realized within our lifetime is largely irrelevant. What we must do therefore is to strive and persevere and never give up.
Thus the will to power strives towards oppositions, towards displeasure. There is a will to suffering at the foundation of all organic life (contrary to "happiness" as "goal").