Of what significance is one's existence, one is basically unaware. What does a fish know about the water in which he swims all his life? The bitter and the sweet come from outside. The hard from within, from one's own efforts. For the most part I do what my own nature drives me to do. It is embarrassing to earn such respect and love for it.
What are people searching for in life? God. In the christian scriptures, it says 'Be still and know you are God.' What is this? You are peace, compassion, truth, Love, freedom. Real love- the ability to love yourself so much that you forgive everything and you are at peace with yourself like a mother loves a child, not trying to be someone.
The ascent to the divine Life is the human journey, the Work of works, the acceptable Sacrifice. This alone is man's real business in the world and the justification of his existence, without which he would only be an insect crawling among the ephemeral insects on a speck of surface mud and water which has managed to form itself amid the appalling immensities of the physical universe.