Much of human history can, I think, be described as a gradual and sometimes painful liberation from provincialism, the emerging awareness that there is more to the world than was generally believed by our ancestors.
In this troublesome world, we are never quite satisfied. When you were here, I thought you hindered me some in attending to business; but now, having nothing but business---no variety---it has grown exceedingly tasteless to me. I hate to sit down and direct documents, and I hate to stay in this old room by myself.
Science, already oppressive with its shocking revelations, will perhaps be the ultimate exterminator of our human species - if separate species we be - for its reserve of unguessed horrors could never be borne by mortal brains if loossed upon the world.