There is no other species on Earth that does science. It is, so far, entirely a human invention, evolved by natural selection in the cerebral cortex for one simple reason: it works. It is not perfect. It can be misused. It is only a tool. But it is by far the best tool we have, self-correcting, ongoing, applicable to everything.
Ask courageous questions.
Do not be satisfied with superficial answers.
Be open to wonder and at the same time subject all claims to knowledge, without exception, to intense skeptical scrutiny.
Be aware of human fallibility.
Cherish your species and your planet.
But the fact that some geniuses were laughed at does not imply that all who are laughed at are geniuses. They laughed at Columbus, they laughed at Fulton, they laughed at the Wright Brothers. But they also laughed at Bozo the Clown.
Many statements about God are confidently made by theologians on grounds that today at least sound specious. Thomas Aquinas claimed to prove that God cannot make another God, or commit suicide, or make a man without a soul, or even make a triangle whose interior angles do not equal 180 degrees. But Bolyai and Lobachevsky were able to accomplish this last feat (on a curved surface) in the nineteenth century, and they were not even approximately gods.
I believe that part of what propels science is the thirst for wonder. It's a very powerful emotion. All children feel it. In a first grade classroom everybody feels it; in a twelfth grade classroom almost nobody feels it, or at least acknowledges it. Something happens between first and twelfth grade, and it's not just puberty. Not only do the schools and the media not teach much skepticism, there is also little encouragement of this stirring sense of wonder. Science and pseudoscience both arouse that feeling. Poor popularizations of science establish an ecological niche for pseudoscience.
If you look at Earth from space you see a dot, that's here. That's home. That's us. It underscores the responsibility to deal more kindly and compassionately with one another and to preserve and cherish that pale blue dot, the only home we've ever known.
Where did God come from? If we decide this is an unanswerable question why not save a step and conclude that the origin of the universe is an unanswerable question.