To have a body is to suffer. Does anyone with a body know peace? Those who understand this detach themselves from all that exists and stop imagining or seeking anything. The sutras say, "To seek is to suffer. To seek nothing is bliss." When you seek nothing, you're on the Path.
I think one of the defining moments of adulthood is the realization that nobody's going to take care of you. That you have to do the heavy lifting while you're here. And when you don't, well, you suffer the consequences.
The saddest thing in life and the hardest to live through, is the knowledge that there is someone you love very much whom you cannot save from suffering.
Received as I am by the members of a legislature the majority of whom do not agree with me in political sentiments, I trust that I may have their assistance in piloting the ship of state through this voyage, surrounded by perils as it is; for if it should suffer wreck now, there will be no pilot ever needed for another voyage.
When you begin to become conscious, more aware, when your eyes begin to open, the first thing you see is how deluded you are and how much you're holding onto that which makes you suffer. This is, in many ways, the most important step: Are you willing to be aware?