Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.
To a large degree, since the beginning of time, charisma or the lack of it has impacted upon those in quest of acclaim. As media expands, this has become ever more vital. Thus, demeanor if unappealing, can defeat one's likelihood of success, causing the death of prospects whilst they are still embryonic.
The power of the human will to compete and the drive to excel beyond the body's normal capabilities is most beautifully demonstrated in the arena of sport.
Success in your work, the finding a better method, the better understanding that insures the better performing is hat and coat, is food and wine, is fire and horse and health and holiday. At least, I find that any success in my work has the effect on my spirits of all these.
Don't aim for success if you want it; just do what you love and believe in, and it will come naturally. Despite everything, I believe that people are really good at heart.