Remember the Three Princes of Serendip who went out looking for treasure? They didn't find what they were looking for, but they kept finding things just as valuable. That's serendipity, and our business [drugs] is full of it.
The human understanding is moved by those things most which strike and enter the mind simultaneously and suddenly, and so fill the imagination; and then it feigns and supposes all other things to be somehow, though it cannot see how, similar to those few things by which it is surrounded.
Thinking is seeing.... Every human science is based on deduction, which is a slow process of seeing by which we work up from the effect to the cause; or, in a wider sense, all poetry like every work of art proceeds from a swift vision of things.
[My advice] will one day be found
With other relics of 'a former world,'
When this world shall be former, underground,
Thrown topsy-turvy, twisted, crisped, and curled,
Baked, fried or burnt, turned inside-out, or drowned,
Like all the worlds before, which have been hurled
First out of, and then back again to Chaos,
The Superstratum which will overlay us.
Torrent of light and river of air,
Along whose bed the glimmering stars are seen,
Like gold and silver sands in some ravine
Where mountain streams have left their channels bare!
[Newton wrote to Halley ... that he would not give Hooke any credit] That, alas, is vanity. You find it in so many scientists. You know, it has always hurt me to think that Galileo did not acknowledge the work of Kepler.
LEAD, n. A heavy blue-gray metal much used ... as a counterpoise to an argument of such weight that it turns the scale of debate the wrong way. An interesting fact in the chemistry of international controversy is that at the point of contact of two patriotisms lead is precipitated in great quantities.
Man is a little germ that lives on an unimportant rock ball that revolves about a small star at the outskirts of an ordinary galaxy. ... I am absolutely amazed to discover myself on this rock ball rotating around a spherical fire. It's a very odd situation. And the more I look at things I cannot get rid of the feeling that existence is quite weird.
The End of our Foundation is the knowledge of Causes; and secret motions of things; and the enlarging of the bounds of Human Empire, to the effecting of all things possible.
Pure mathematics is, in its way, the poetry of logical ideas. ... [By seeking] logical beauty spiritual formulas are discovered necessary for the deeper penetration into the laws of nature.
Bread has been made (indifferent) from potatoes;
And galvanism has set some corpses grinning,
But has not answer'd like the apparatus
Of the Humane Society's beginning,
By which men are unsuffocated gratis:
What wondrous new machines have late been spinning.