Ye may kill for yourselves, and your mates, and your cubs as they need, and ye can; But kill not for pleasure of killing, and seven times never kill Man!
At a certain point we need to grow up; we need to look inside ourselves for our inner guidance. There are things most human beings know; they just don't want to know them. They know deep down that certain things in their lives are working or aren't working, that certain parts of their lives are functional and others are dysfunctional. But sometimes, as human beings, we don't want to know what's not convenient. So we pretend not to know.
You've got to do the big studio movies to get your name, but as an actor and for your own well-being you kind of need to step back from that occasionally and do the smaller films. In the end, that's what helps you learn and makes you a better actor.
The rule I have when choosing films is the excitement factor, I need to feel excited about the story and whatever message the film has - only then do I sign on the dotted line.