People often expect the other person to respond first in a positive way, instead of taking the initiative to create that possibility. I feel that's wrong; it can act as a barrier that just promotes a feeling of isolation from others. To overcome feelings of isolation and loneliness, your underlying attitude makes a tremendous difference - approaching others with the thought of compassion in your mind is the best way.
To remain indifferent to the challenges we face is indefensible. If the goal is noble, whether or not it is realized within our lifetime is largely irrelevant. What we must do therefore is to strive and persevere and never give up.
Giving up attachment to the world does not mean that you set yourself apart from it. Generating a desire for others to be happy increases your humanity. As you become less attached to the world, you become more humane. As the very purpose of spiritual practice is to help others, you must remain in society.
When we are young and again when we are old, we depend heavily on the affection of others. Between these stages we usually feel that we can do everything without help from others and that other people's affection is simply not important. But at this stage I think it is very important to keep deep human affection.
I believe compassion to be one of the few things we can practice that will bring immediate and long-term happiness to our lives. I'm not talking about the short-term gratification of pleasures like sex, drugs or gambling (though I'm not knocking them), but something that will bring true and lasting happiness. The kind that sticks.
Dangerous consequences will follow when politicians and rulers forget moral principles. Whether we believe in God or karma, ethics is the foundation of every religion.