Remember the Three Princes of Serendip who went out looking for treasure? They didn't find what they were looking for, but they kept finding things just as valuable. That's serendipity, and our business [drugs] is full of it.
Science is a wonderful thing if one does not have to earn one's living at it. One should earn one's living by work of which one is sure one is capable. Only when we do not have to be accountable to anybody can we find joy in scientific endeavor.
If someone separated the art of counting and measuring and weighing from all the other arts, what was left of each (of the others) would be, so to speak, insignificant.
The usual derivation of the word Metaphysics is not to be sustainedthe science is supposed to take its name from its superiority to physics. The truth is, that Aristotle's treatise on Morals is next in succession to his Book of Physics.
That is the way of the scientist. He will spend thirty years in building up a mountain range of facts with the intent to prove a certain theory; then he is so happy with his achievement that as a rule he overlooks the main chief fact of all-that all his accumulation proves an entirely different thing.
LEAD, n. A heavy blue-gray metal much used ... as a counterpoise to an argument of such weight that it turns the scale of debate the wrong way. An interesting fact in the chemistry of international controversy is that at the point of contact of two patriotisms lead is precipitated in great quantities.
[My advice] will one day be found
With other relics of 'a former world,'
When this world shall be former, underground,
Thrown topsy-turvy, twisted, crisped, and curled,
Baked, fried or burnt, turned inside-out, or drowned,
Like all the worlds before, which have been hurled
First out of, and then back again to Chaos,
The Superstratum which will overlay us.
I am exclusively occupied with the problem of gravitation and hope with the help of a local mathematician friend [Marcel Grossman] to overcome all the difficulties. One thing is certain, however, that never in life have I been quite so tormented. A great respect for mathematics has been instilled within me, the subtler aspects of which, in my stupidity, I regarded until now as pure luxury.
For many parts of Nature can neither be invented with sufficient subtlety, nor demonstrated with sufficient perspicuity, nor accommodated unto use with sufficient dexterity, without the aid and intervening of the mathematics, of which sort are perspective, music, astronomy, cosmography, architecture, engineery, and divers others.
Nor has science sufficient humanity, so long as the naturalist overlooks the wonderful congruity which subsists between man and the world; of which he is lord, not because he is the most subtile inhabitant, but because he is its head and heart, and finds something of himself in every great and small thing, in every mountain stratum, in every new law of color, fact of astronomy, or atmospheric influence which observation or analysis lay open.
Widespread intellectual and moral docility may be convenient for leaders in the short term, but it is suicidal for nations in the long term. One of the criteria for national leadership should therefore be a talent for understanding, encouraging, and making constructive use of vigorous criticism.